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Characterization of N-acetamide indoles as antimalarials that target PfATP4

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NIAID Data Ecosystem2026-05-02 收录
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To discover new antimalarial chemotypes a phenotypic screen of the Janssen Jumpstarter library against the P. falciparum asexual stage was undertaken and uncovered the N-acetamide indoles structural hit class. Forward genetics uncovered that N-acetamide indoles resistant parasites have mutations in PfATP4.

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2025-01-27
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