Additional file 1 of Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

: Figure S1 Genetic ablation of cIAP1 attenuates denervation-induced atrophy. A small (5–10 mm) piece of the right sciatic nerve was removed to induce denervation of the entire right hind limb of 6-week-old C57BL/6 mice (blue bars) or sex- and age-matched cIAP1-null mice (orange bars). The contralateral leg served as an internal control. Mice were sacrificed 7 days post-denervation. (A) Representative images of TA muscle sections stained with H&E from mice described above. (B) Decrease in TA fiber size as a percentage of non-denervated control leg cross-sectional area (n ≥ 2). Data is the mean ± SEM, n.s. not significant. (ZIP 350 kb)