Measuring and Modeling Macrophage Growth Using a Lab-on-CMOS Capacitance Sensing Microsystem

 In this archive, we provide experimental data and software that were used in our study on macrophage proliferation using a lab-on-CMOS platform.  The data are for RAW 264.7 murine Balb/c macrophages, which we cultured on a CMOS capacitance sensor. We show that macrophage growth over a wide sensing area correlates linearly with an average capacitance growth factor resulting from capacitance measurements at a plurality of electrodes dispersed in the sensing area. We further show a temporal model that captures the cell evolution in the area of interest over long periods (e.g., 30 hours). The model links the cell numbers and the average capacitance growth factor associated with the sensing area to describe the observed growth kinetics.