Replication Data for: Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale county, coastal Kenya.

This is a replication dataset for the manuscript titled: "Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale county, coastal Kenya." Bed bugs (Cimex spp.) are obligate ectoparasites that have long been associated with human dwellings, causing discomfort and psychosocial distress. Conventional control strategies relying on insecticides are increasingly challenged by resistance, necessitating alternative interventions. Ivermectin, an endectocide known to impact hematophagous arthropods, is currently being assessed for malaria vector control. This study aimed to evaluate the toxicity of ivermectin on Cimex hemipterus, the predominant bed bug species in Africa, within the framework of the BOHEMIA project in Kwale, Kenya. A cross-sectional survey was done in 2393 households to obtain information on self-reported bed bug infestations, socio economic status, and household characteristics. Bed bugs were collected from 40 infested households in the control arm of the BOHEMIA trial. After collection, bed bugs were acclimatized and exposed to blood meals spiked with ivermectin at five concentrations (11 ng/ml, 21 ng/ml, 43 ng/ml, 64 ng/ml, and 85 ng/ml), corresponding to expected serum levels following a 400 mcg/kg oral dose. Mortality and fecundity were monitored over a 14-day period. Statistical analyses, including Cox proportional hazard models and probit regression, were applied to assess dose-response relationships.