Standardized incidence ratios (SIRs) for malignancies in Japan-resident Werner syndrome patients.^***

*statistically significant result (p<0.05). **includes benign meningiomas diagnosed prior to 1988, but excludes non-melanoma skin neoplasms. ***for patients with high WS diagnostic confidence (1965–2009). ****relative to Osaka, Japan population, 1965–2009. note: analysis conditioned on a WRN pathogenic allele frequency of q = 0.0037.