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Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides

NIAID Data Ecosystem2026-05-02 收录

HCV聚合酶

抗病毒药物合成与表征

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Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides

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创建时间：

2024-10-30

HCV聚合酶

结构生物学

Structure of the genotype 2B HCV polymerase Descriptor: RNA-directed RNA polymerase Authors: Rydberg, E.H, Carfi, A. Deposit date: 2009-03-27 Release date: 2009-07-07 Last modified: 2026-03-04 Method:

Protein Data Bank Japan2026-03-04 更新50

A Cell-Based Assay for RNA Synthesis by the HCV Polymerase Reveals New Insights on Mechanism of Polymerase Inhibitors and Modulation by NS5A

HCV聚合酶

抗病毒药物

RNA synthesis by the genotype 1b hepatitis C virus (HCV) polymerase (NS5B) transiently expressed in Human embryonic kidney 293T cells or liver hepatocytes was found to robustly stimulate RIG-I-depende

NIAID Data Ecosystem30

A Cell-Based Assay for RNA Synthesis by the HCV Polymerase Reveals New Insights on Mechanism of Polymerase Inhibitors and Modulation by NS5A

HCV聚合酶

抗病毒药物

Figshare2016-01-18 更新20

CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU

HCV聚合酶

抗病毒药物靶点

CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE

Protein Data Bank Japan2023-09-27 更新30

HCV NS5B GT1A with GSK5852

抗病毒药物研发

HCV聚合酶

HCV NS5B GT1A with GSK5852 Descriptor: HCV Polymerase, SULFATE ION, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic ac

Protein Data Bank Japan2024-03-13 更新30

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides

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