Association of specific biotypes in patients with Parkinson's disease and disease progression
收藏DataONE2020-10-26 更新2025-07-19 收录
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Objective
To identify biotypes in newly diagnosed Parkinsonâs disease patients and test whether these biotypes could explain inter-individual differences in longitudinal progression.
Methods
In this longitudinal analysis, we use a data-driven approach clustering PD patients from the Parkinsonâs Progression Markers Initiative (PPMI) (n = 314, age = 61.0 ± 9.5, 34.1% female, 5 years follow-up). Voxel-level neuroanatomical features were estimated using deformation-based morphometry (DBM) of T1-weighted MRI. Voxels whose deformation values were significantly correlated (P < 0.01) with clinical scores (MDS-UPDRS-Parts I-III, MDS-UPDRS-total, tremor score, and postural instability and gait difficulty score) at baseline were selected. Then, these neuroanatomical features were subjected to hierarchical cluster analysis. Changes in the longitudinal progression and neuroanatomical pattern were compared between different biotypes.
Results
Two neuroanatomical biotypes were iden...
创建时间：
2025-06-28
