Transcriptomic analysis of WAT from male mice innately exhibiting various susceptibility to diet-induced-obesity: samples from mice at T0

To identify candidate predictive markers, our study used two mouse models: one of them consists in Balb/c adult male mice exhibiting interindividual variability in obesity predisposition. A HFD challenge of 18 weeks allow to classify each mice according to its susceptibility to obesity. Transcriptomic analysis was performed on biopsies of White adipose tissues sample from 27 mice before the HFD Challenge.为筛选潜在的预测性生物标志物，本研究采用两种小鼠模型：其中一种为Balb/c成年雄性小鼠，该种群在肥胖易感性方面存在个体间差异。通过为期18周的高脂饮食（High Fat Diet, HFD）造模干预，可依据每只小鼠的肥胖易感性完成分组归类。在高脂饮食干预前，研究人员对27只小鼠的白色脂肪组织（White Adipose Tissue, WAT）活检样本开展了转录组学分析。