Loci with significant interaction between fish oil supplementation and blood lipid levels.

Listed variants represent the lead association within a 1 Mb region for 1df tests of variant × fish oil interaction after meta-analysis. The name of the nearest gene is listed with each lead variant. Bold P-values indicate meeting the genome-wide significance threshold of P < 5 × 10−8. Main effect P-values are calculated using Stage 1 (UK Biobank) participants only, and without interaction (Eq (2); stratified for exposure groups as in Eq (3)). Effect, beta coefficient of the minor allele dose term (βG in Eq (1)); MAF, minor allele frequency; SE, standard error; Int effect, beta coefficient of the interaction term (βG×EG×E in Eq (1)). Lipid traits were measured in mmol/L.