Sequence Read Archive

The SRA is NIH's primary archive of high-throughput sequencing data and is part of the International Nucleotide Sequence Database Collaboration (INSDC) that includes at the NCBI Sequence Read Archive (SRA), the European Bioinformatics Institute (EBI), and the DNA Database of Japan (DDBJ). Data submitted to any of the three organizations are shared among them. SRA accepts data from all kinds of sequencing projects including clinically important studies that involve human subjects or their metagenomes, which may contain human sequences. These data often have a controlled access via dbGaP (the database of Genotypes and Phenotypes).

序列读取档案（Sequence Read Archive, SRA）是美国国立卫生研究院（National Institutes of Health, NIH）高通量测序数据的核心存档库，隶属于国际核苷酸序列数据库协作组（International Nucleotide Sequence Database Collaboration, INSDC）。该协作组涵盖美国国家生物技术信息中心（National Center for Biotechnology Information, NCBI）序列读取档案（SRA）、欧洲生物信息研究所（European Bioinformatics Institute, EBI）与日本DNA数据库（DNA Database of Japan, DDBJ）三家成员。向任意一家机构提交的数据均可在成员间实现共享。SRA接收各类测序项目产生的数据，包括涉及人类受试者或其宏基因组（可能包含人类序列）的临床重要性研究数据。此类数据通常需通过基因型与表型数据库（database of Genotypes and Phenotypes, dbGaP）实施受控访问。

搜集汇总

背景与挑战

背景概述

该数据集是美国国立卫生研究院（NIH）的高通量测序数据核心存储库，隶属于国际核苷酸序列数据库合作组织（INSDC），与欧洲生物信息学研究所（EBI）和日本DNA数据库（DDBJ）共享数据。它收录包括临床研究在内的各类测序项目数据，部分涉及人类的数据可通过dbGaP进行受控访问。