iGEMME Missense Mutational Effect Predictions for Entire Human Proteome

This dataset contains iGEMME single point mutation predictions of about ~19000 human proteins. In iGEMME predictions, only evolutionary data coming from multiple sequence alignment files is used. Description of the data and file structure This dataset contains iGEMME predictions for all human proteins. Data of each human protein is in a folder named after its uniprotID. Inside uniprotID folder, there is a subfolder called results that contain all input and output. An example results folder for uniprotID A0A0B4J245 will contain the following files: Raw igemme predictions (output file): A0A0B4J245_normPred_evolCombi_igemme.txt Ranksorted (between 0-1) igemme predictions in csv format (output file): A0A0B4J245_normPred_evolCombiTransposedRanksorted_igemme.csv Colabfold MSA file (input file): aliA0A0B4J245.fasta JET2 file containing JET scores for each amino acid (output file) : A0A0B4J245_jet_igemme.res Configuration file containing default parameters (output file): default.conf Log file (output file): igemme.log本数据集包含约19000个人类蛋白质的iGEMME单点突变预测结果。在iGEMME预测流程中，仅使用源自多序列比对文件的进化数据。 数据与文件结构说明： 本数据集涵盖所有人类蛋白质的iGEMME预测结果。每个人类蛋白质的数据均存储于以其UniProtID命名的文件夹中。在该UniProtID文件夹内，设有一个名为results的子文件夹，用于存放所有输入与输出文件。以UniProtID为A0A0B4J245的示例results文件夹为例，其将包含以下文件： 1. 原始iGEMME预测结果（输出文件）：A0A0B4J245_normPred_evolCombi_igemme.txt 2. 经0至1区间排序的iGEMME预测结果（CSV格式，输出文件）：A0A0B4J245_normPred_evolCombiTransposedRanksorted_igemme.csv 3. Colabfold多序列比对（Multiple Sequence Alignment, MSA）文件（输入文件）：aliA0A0B4J245.fasta 4. 包含各氨基酸JET评分的JET2文件（输出文件）：A0A0B4J245_jet_igemme.res 5. 存储默认参数的配置文件（输出文件）：default.conf 6. 日志文件（输出文件）：igemme.log