Effectiveness of HIV Pre-Exposure Prophylaxis (PrEP): A Meta-Analysis of 100 Studies (2000–2025)

This document presents a comprehensive meta-analysis of 100 studies published between 2000 and 2025 on the effectiveness of HIV pre-exposure prophylaxis (PrEP). It synthesizes findings from randomized controlled trials and observational studies across diverse populations, including MSM, serodiscordant couples, people who inject drugs, and high-risk heterosexuals. The analysis highlights adherence as the most critical factor influencing PrEP efficacy, evaluates safety outcomes, and compares oral versus injectable PrEP regimens. Results confirm that PrEP is a safe, effective, and essential component of global HIV prevention strategies. Policy recommendations emphasize adherence support, equitable access, and integration into primary healthcare systems.本研究针对2000年至2025年间发表的100项相关研究开展了全面的元分析，聚焦人类免疫缺陷病毒（HIV）暴露前预防（pre-exposure prophylaxis, PrEP）的有效性。本研究整合了覆盖不同人群的随机对照试验与观察性研究结果，研究对象包括男男性行为者（men who have sex with men, MSM）、血清学不一致伴侣、注射毒品使用者以及高危异性性行为人群。本元分析强调服药依从性是影响PrEP有效性的最关键因素，同时评估了相关安全性结局，并对比了口服与注射型PrEP给药方案。研究结果证实，PrEP是全球HIV预防策略中安全、有效且不可或缺的组成部分。相关政策建议着重强调需加强服药依从性支持、保障公平可及性，并推动PrEP融入初级医疗卫生体系。