Basal activity and activation of WT and modified GLP-1 and GIP receptors by their respective ligands.

The mean ± S.E.M shown are from at least 3 independent experiments (the number of experiments is shown in brackets). pEC50 refers to −logEC50/M.*Basal activity significantly higher than corresponding GLP-1R modification (P#basal activity significantly lower than WT GIPR (P***basal activity significantly higher than the corresponding GLP-1R modification (PBasal activity and activation of WT and modified GLP-1 and GIP receptors by their respective ligands.