Psychological Impact of Melanoma Study - Supplemental Material

Supplemental Methods The study utilized the TriNetX US Collaborate Network to identify melanoma patients diagnosed between 2009-2019. Propensity matching was performed to create three melanoma cohorts (stages I, II, III/IV) and two control cohorts (basal cell carcinoma, hypertension treated with lisinopril). Patients with pre-diagnosis psychological outcomes were excluded. Supplemental Table Outcome measures included risk ratios for anxiety, depression, and antidepressant prescriptions at 3, 12, and 36 months post-melanoma diagnosis across melanoma stages, compared to controls.补充方法 本研究依托TriNetX美国协作网络（TriNetX US Collaborate Network），筛选出2009年至2019年间确诊的黑色素瘤（melanoma）患者。通过倾向匹配法构建3组黑色素瘤队列（Ⅰ期、Ⅱ期、Ⅲ/Ⅳ期）与2组对照队列：分别为基底细胞癌（basal cell carcinoma）患者队列，以及接受赖诺普利（lisinopril）治疗的高血压（hypertension）患者队列。本研究排除诊断前已存在心理相关结局的患者。 补充表格 本研究的结局指标涵盖：按黑色素瘤分期分层，与对照组相比，黑色素瘤确诊后3、12、36个月时的焦虑、抑郁发生风险及抗抑郁药物处方的风险比（risk ratio）。