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N-Heterocyclic Carbene (NHC)-Catalyzed Highly Diastereo- and Enantioselective Oxo-Diels–Alder Reactions for Synthesis of Fused Pyrano[2,3-b]indoles

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Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_i_N_i_Heterocyclic_Carbene_NHC_Catalyzed_Highly_Diastereo_and_Enantioselective_Oxo_Diels_Alder_Reactions_for_Synthesis_of_Fused_Pyrano_2_3_i_b_i_indoles/2518123
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A chiral N-heterocyclic carbene (NHC)-catalyzed Diels–Alder reaction of 2-oxoindolin-3-ylidenes and α-chloroaldehydes was developed for the synthesis of fused pyrano[2,3-b]indoles in good to excellent yields (up to 99%) with high cis-diastereoselectivities (>99:1 dr) and enantioselectivities (up to >99% ee).
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2016-02-20
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