Gene copy numbers for major bacterial groups per gram of feces from the same animals over time in CPT-11/5-FU regimen.

CPT-11 and 5-FU were administered as shown in Figure 1B. Shown are gene copy numbers of total bacteria, Bacteroides group (Bacteroid.), Lactobacillus group (Lactobact.), Bifidobacterium species (Bifidobact.) the Clostridium clusters I, IV, XI, and XIV, and Enterobacteriaceae (Enterobact). Data are shown as mean of six animals (pooled standard error of the mean). Values in the same column that do not share a common superscript differ significantly (P≤0.05). Superscripts are omitted for those bacterial groups that did not exhibit significant changes during the experiment.
Samples were taken from the same animal prior to tumor implantation (ref.), at 0 d (prior to chemotherapy), 7 d (prior to the second cycle of thermotherapy), and 10 and 11 d (one and two days, respectively, after the second cycle of chemotherapy).