Steroid hormone precursor biosynthesis

Biosynthesis of steroid hormone precursors. The enzymes responsible for this process are mainly cytochrome P450 (Cyps), hydroxysteroid dehydrogenases (HSDs), and steroid reductases, converting cholesterol to several classes of steroid hormones such as glucocorticoids, mineralocorticoids, progestins, androgens, and estrogens. these reactions take place in various organs, e.g. adrenal gland, testis, ovary, brain, placenta, and adipose tissue [PMID:16807284]. The pathway knowledge depicted in this model stems from William Griffths. Metabolic reactions currently without a Rhea ID have been added in bold to the pathway model.

类固醇激素前体的生物合成。负责此过程的酶主要为细胞色素P450（Cyps）、羟基类固醇脱氢酶（HSDs）和类固醇还原酶，它们将胆固醇转化为多种类固醇激素，如糖皮质激素、盐皮质激素、孕激素、雄激素和雌激素。这些反应发生在多种器官中，例如肾上腺、睾丸、卵巢、大脑、胎盘和脂肪组织 [PMID:16807284]。本模型中描述的通路知识源自威廉·格里菲斯。路径模型中尚未拥有Rhea ID的代谢反应已以粗体形式添加。