Myocardial Infarction Genetics Exome Sequencing Consortium: Jackson Heart Study

This sub-study [phs001069](http://./study.cgi?study_id=phs001069) MIGen JHS contains sample phenotype and sequence data of subjects available from the [phs001069](http://./study.cgi?study_id=phs001069) study. Summary level phenotypes for the NHLBI JHS Cohort study participants can be viewed at the top-level study page [phs000286](./study.cgi?study_id=phs000286) JHS Cohort. Individual level data and sequence data for all JHS Cohort top-level study and substudies are available by requesting Authorized Access to the NHLBI JHS Cohort [phs000286](./study.cgi?study_id=phs000286) study.

The [Jackson Heart Study](http://www.jacksonheartstudy.org) (JHS) is a large, community-based, observational study whose participants were recruited from urban and rural areas of the three counties (Hinds, Madison and Rankin) that make up the Jackson, Mississippi, metropolitan statistical area (MSA). Participants were enrolled from each of the 4 recruitment pools: (1) random, 17%, (2) volunteer, 30%, (3) currently enrolled in the [Atherosclerosis Risk in Communities (ARIC) Study](https://www.nhlbi.nih.gov/science/atherosclerosis-risk-communities-aric-study), 31%, and (4) secondary family members, 22%. Recruitment was limited to non-institutionalized adult African Americans 35-84 years old, except in the family cohort where those 21 to 34 years of age were eligible. The final cohort of 5,301 participants includes 6.59% of all African American Jackson MSA residents aged 35-84 (N-76,426, US Census 2000). Major components of each exam include medical history, physical examination, blood/urine analytes and interview questions on areas such as: physical activity; stress, coping and spirituality; racism and discrimination; socioeconomic position; and access to health care. At 12-month intervals after the baseline clinic visit (Exam 1), participants are contacted by telephone to: update information; confirm vital statistics; document interim medical events, hospitalizations, and functional status; and obtain additional sociocultural information. Questions about medical events, symptoms of cardiovascular disease and functional status are repeated annually. Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases (ICD) codes and adjudication of nonfatal events and deaths.

All exome sequencing was performed at the [Broad Institute of MIT and Harvard](https://www.broadinstitute.org/). Sample sequence capture was performed using Agilent SureSelect Human All Exon Kit v2 and sequencing was performed on an Illumina HiSeq 2000 or 2500.