Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24) Descriptor: 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Turnbull, A.P, Flanagan, J.U, Atwell, G.J, Heinrich, D.M, Jamieson, S.M.F, Brooke, D.G, Silva, S, Rigoreau, L.J.M, Trivier, E, Soudy, C, Samlal, S.S, Owen, P.J, Schroeder, E, Raynham, T, Denny, W.A. Deposit date: 2012-10-18 Release date: 2013-11-13 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-beta-hydroxysteroid dehydrogenase (AKR1C3). Bioorg.Med.Chem., 22, 2014

人源17β-羟基类固醇脱氢酶5型与(4-(4-氯苯基)哌嗪-1-基)(吗啉基)甲酮(24)复合物的晶体结构。成分描述：1,2-乙二醇、醛酮还原酶家族1成员C3（AKR1C3, Aldo-keto reductase family 1 member C3）、烟酰胺腺嘌呤二核苷酸磷酸（Nicotinamide Adenine Dinucleotide Phosphate，简称NADP）……。作者：Turnbull, A.P.、Flanagan, J.U.、Atwell, G.J.、Heinrich, D.M.、Jamieson, S.M.F.、Brooke, D.G.、Silva, S.、Rigoreau, L.J.M.、Trivier, E.、Soudy, C.、Samlal, S.S.、Owen, P.J.、Schroeder, E.、Raynham, T.、Denny, W.A.。提交日期：2012年10月18日，发布日期：2013年11月13日，最后修改日期：2023年9月20日。实验方法：X射线衍射（分辨率2.4 Å）。引用：吗啉基脲类是一类新型强效选择性17β-羟基类固醇脱氢酶5型（AKR1C3）抑制剂，相关研究发表于《Bioorg.Med.Chem.》2014年第22卷。