STRING Network Analysis

This file contains the protein-protein interaction analysis dataset that was used in the unpublished manuscript and was further analyzed with the STRING online software.Significantly upregulated mRNAs (2,777 genes; p 10. The resulting 1,848 nodes were processed through STRING v12.0 (Swiss Institute of Bioinformatics; Lausanne; Switzerland) to generate a protein–protein interaction (PPI) network, incorporating evidence from text mining, genomic neighborhood, experimental data, curated databases, co-expression, gene fusion, and co-occurrence, with a minimum confidence score threshold of 0.40. Network modules were defined using the DBSCAN clustering algorithm with an ε parameter of 2. Cluster 1, representing the largest gene set (101 genes), was further analyzed by sorting the top 20 nodes with the highest node degree, resulting in a network comprising 101 nodes and 756 edges. Global network metrics indicated an average node degree of 15, a local clustering coefficient of 0.600, and a PPI enrichment p-value of