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Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma

ChEBI2014-04-15 更新2026-07-21 收录

母细胞瘤靶向治疗

抗癌药物联合疗法

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-46406 数据链接链接失效反馈

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Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma

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创建时间：

2014-04-15

母细胞瘤靶向治疗

PROTAC药物机制

MZ1 is a newly designed pan-BET-targeting PROTAC that binds to target proteins (BET proteins such as BRD2, BRD3, and BRD4) and recruits them to the ubiquitin/protease pathway for selective destruction

NIAID Data Ecosystem70

TABLE 2 from SHP2 Inhibition with TNO155 Increases Efficacy and Overcomes Resistance of ALK Inhibitors in Neuroblastoma

母细胞瘤靶向治疗

药物联合疗效评估

Treatment regimens administered to Kelly xenografts

Figshare2023-12-27 更新60

Inhibiting YAP1 in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells

母细胞瘤靶向治疗

细胞分化

Despite advances in surgical care and chemotherapeutic regimens, the five-year survival rate for Stage IV Hepatoblastoma (HB), the predominant pediatric liver tumor, remains at 27%. YAP1 and β-Catenin

NIAID Data Ecosystem50

Targeting transcription-replication conflicts is an effective therapeutic principle for MYCN-driven neuroblastoma [ChIPseq_IMR5_RNAseqH1]

母细胞瘤靶向治疗

转录复制冲突

Targeting the function of MYC proteins for therapy is a major challenge in tumor biology. MYC proteins are transcription factors that can globally release RNA polymerase II (RNAPII) from core promoter

NIAID Data Ecosystem60

Inhibition of the mRNA-binding protein IGF2BP1 suppresses proliferation and sensitizes neuroblastoma cells to chemotherapeutics

母细胞瘤靶向治疗

药物敏感性协同效应

Gain at chromosome 17q21 in neuroblastoma and is associated with a poor prognosis, independent of MYCN amplification status. Several potential proto-oncogenes have been identified in this region, one

NIAID Data Ecosystem60

Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma

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