Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis

NIAID Data Ecosystem2026-05-01 收录

聚合酶保真度

酶学动力学机制

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Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis

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2023-08-23

A genetic system to identify DNA polymerase β mutator mutants

聚合酶保真度

突变体筛选

DNA polymerase β (pol β) is a 39-kDa protein that functions in DNA repair processes in mammalian cells. As a first step toward understanding mechanisms of polymerase fidelity, we developed a genetic m

PubMed Central1997-02-18 更新50

Identification of Amino Acid Residues Involved in the Fidelity of Influenza Virus Polymerase

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病毒复制机制

The evolution and host adaptation of influenza viruses are facilitated by the highly error-prone replication process catalyzed by the viral RNA-dependent RNA polymerase. However, amino acid residues

NIAID Data Ecosystem30

Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis

聚合酶保真度

分子生物学实验

Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*(DOC)-3')

Protein Data Bank Japan2024-05-22 更新30

Error rate of KlenTaq wild-type and KlenTaq R660V.

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基因复制错误率

aNumber of mutations per 650 bases (KlenTaq wild-type) or 726 bases (R660V) sequenced per clone.bError rate equals number of mutations per base per division.cData taken from [63].

Figshare2015-12-02 更新40

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

聚合酶保真度

抗病毒诱变剂筛选

In a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amilori

NIAID Data Ecosystem30

Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis

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