Inflammatory Bowel Disease Genetics

The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) and cell line repository was created in 2002 by the National Institute of Diabetes, Digestive and Kidney diseases (NIDDK) to advance knowledge on the inflammatory bowel diseases, specifically Crohn’s Disease and Ulcerative Colitis. The Consortium consists of six genetic research centers (GRC) and a data coordinating center (DCC) that prospectively recruits a combination of cases, controls, and trios to gather a large collection of samples and linked phenotype information. Phenotyping is performed using a standardized protocol, and lymphoblastoid cell lines are established for each subject. The resulting DNA samples are used to conduct genetic linkage and association studies. The IBDGC is involved with independent genetic research studies and actively works with members of the IBD and genetic communities on collaborative projects.

美国国家糖尿病、消化和肾脏疾病研究所（National Institute of Diabetes, Digestive and Kidney Diseases, NIDDK）于2002年创建了炎症性肠病遗传学联盟（Inflammatory Bowel Disease Genetics Consortium, IBDGC）及其细胞系库（cell line repository），旨在深化对炎症性肠病的研究认知，尤其聚焦克罗恩病（Crohn’s Disease）与溃疡性结肠炎（Ulcerative Colitis）两大病种。该联盟下设6家遗传研究中心（Genetic Research Centers, GRC）与1家数据协调中心（Data Coordinating Center, DCC），通过前瞻性招募病例、对照个体及核心家系（trios）样本，采集大规模的样本资源与关联表型信息。表型分型工作采用标准化流程开展，并为每位受试者建立淋巴母细胞系（lymphoblastoid cell lines）。所获取的DNA样本可用于开展遗传连锁与关联分析研究。该联盟既独立推进遗传相关研究项目，也积极联合炎症性肠病领域与遗传学领域的从业者开展合作课题。