Data for: Change in the pattern of posttransplantation anemia in kidney receptors. Gender role in recipients and type of donor

Introduction: Posttransplant anemia (PTA) in kidney organ receptors is a complication that has repercussions mainly of cardiovascular consequence. The objective of this study is to determine the prevalence of anemia, as well as the relationship between gender in the kidney recipient and the kidney donor, in the presence or absence of anemia at 12 months’ post kidney transplant (KT).
Material and methods: Observational, longitudinal study of KT made over a 5-year period, from 2013 to 2017 in renal transplant unit from "La Raza" National Healthcare Medical Center. Three hundred twenty-eight records were analyzed. Hemoglobin (Hb) and the presence or absence of anemia according to the definition of the World Health Organization were analyzed; the association was determined between the gender of the kidney recipient and donor type (Living or deceased). For the analysis central tendency and dispersion were made, the mean difference was established with chi squared test or student’s t-test. For bivariate risk analysis was performed with significant p<0.05.
Results: The mean Hb before KT was 10.38 g / dL (SD ± 2.16); Hb at 12 months was 14.47 g / dL (SD ± 2.37) 4.09 absolute increase g / dL. Kidney organ male recipients a mean of 10.54 g Hb / dL (SD ± 2.17) at 12 months 15.33 g / dL (SD ± 2.25), Δ 4.79 g / dL; female recipients Hb 10.16 g / dL (SD ± 2.13) to 13.31 g / dL (2.01 ± DE), 3.15 g of Δ g/ dL Hb, the difference between genders was 1.64 g / dL at the end of 12 months. Patients with serum creatinine (Cr) <1.2 mg / dl and anemia were 16/152 (10.5%); patients with Cr≥1.2 mg / dL and anemia were 36/176 (20.5%), p 0.014. In the bivariate logistic regression with an OR of 2.047 (95% CI 1027-4078, p=0.042) for higher Cr levels and the presence of persistent anemia.
Conclusions: There is a prevalence of anemia in female kidney organ recipients and kidney organ recipients from deceased donors. There is a higher risk of persistent anemia in the case of patients with some degree of graft failure at 12 months.

Keywords: posttransplantation anemia, hemoglobin pattern post-transplant, gender, anemia pattern between type of donor in kidney transplantation

引言：移植后贫血（PTA）是肾脏器官受体所面临的并发症，其主要影响为心血管系统。本研究旨在确定移植后12个月贫血的患病率，以及肾脏受体性别与供体性别（活体或尸体）之间，在存在或不存在贫血情况下的关联。

材料与方法：本项研究为2013年至2017年在“La Raza”国家医疗保健中心肾脏移植单元进行的为期5年的纵向观察研究。分析了328份记录。对血红蛋白（Hb）及根据世界卫生组织定义的贫血是否存在进行了分析；确定了肾脏受体性别与供体类型（活体或尸体）之间的关联。进行了集中趋势和离散程度的分析，使用卡方检验或t检验确定了均值差异。对于双变量风险分析，p值小于0.05。

结果：移植前血红蛋白均值为10.38 g/dL（标准差±2.16）；12个月时的血红蛋白均值为14.47 g/dL（标准差±2.37），绝对增加4.09 g/dL。肾脏器官男性受体的血红蛋白均值为10.54 g/dL（标准差±2.17），12个月时为15.33 g/dL（标准差±2.25），增加4.79 g/dL；女性受体的血红蛋白均值为10.16 g/dL（标准差±2.13）至13.31 g/dL（标准差±2.01），血红蛋白增加3.15 g/dL，12个月结束时性别间的差异为1.64 g/dL。血清肌酐（Cr）<1.2 mg/dL且存在贫血的患者为16/152（10.5%）；Cr≥1.2 mg/dL且存在贫血的患者为36/176（20.5%），p值为0.014。在双变量逻辑回归中，对于更高Cr水平和持续贫血的存在，比值比（OR）为2.047（95%置信区间1027-4078，p=0.042）。

结论：女性肾脏器官受体和尸体供体肾脏器官受体中存在贫血的普遍性。在12个月时，出现一定程度移植物功能衰竭的患者中，持续贫血的风险更高。

关键词：移植后贫血，移植后血红蛋白模式，性别，肾脏移植中供体类型之间的贫血模式