High-fat diets promote peritoneal inflammation and augment endometriosis-associated hyperalgesia

Immune dysfunction is a central component in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation to cause metabolic and chronic inflammatory diseases, and are also considered an environmental risk factor for gynecologic diseases. Thus, we examined how HFD alters gut microbiota. The present results showed that the diversity and composition of the gut microbiota were clearly altered by HFD as a sign of low-grade systemic inflammation.