Analysis of epigenome reprogramming and pre-malignant transformation in bronchial epithelial cell lines
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121433
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资源简介：
An in vitro model of pre-malignancy was used to evaluate the role of double-strand break DNA repair capacity in transformation of hTERT/CDK4 immortalized human bronchial epithelial cells and reprogramming of the epigenome. Remove probes on X and Y chromosomes, detection p-value >0.01 and/or outside TSS1500-1st Exon genomic region. Analysis was restricted to probes for genes found to be methylated in TCGA lung cancer tumors and change in beta values was assessed in transformed clones compared to vehicle treated control cell lines. Bisulphite converted DNA from the 8 samples were hybridized to the Illumina MethylationEPIC Beadchip
创建时间：
2020-10-21
