BIOGRID CURATED DATA FOR MSB3 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for MSB3 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; required for proper actin organization; also localizes to plasma membrane and sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to the TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication

蛋白-蛋白、遗传和化学相互作用数据集，针对酵母菌（Saccharomyces cerevisiae S288c）中的MSB3（Rab GTPase激活蛋白）进行整理，由BioGRID（https://thebiogrid.org）维护；定义：Rab GTPase激活蛋白；通过失活Vps21p于内体和溶酶体融合以及失活Ypt7p于溶酶体来调节内吞作用；亦作用于Ypt52p和Sec4p；对正确肌动蛋白组织至关重要；亦定位于质膜和极性生长部位；在DNA复制压力下，从芽颈重新定位至细胞质；与TBC结构域的Tre2癌基因相似；MSB3有一个同源基因MSB4，该基因起源于全基因组复制。