Genome-wide chromatin localization profiling of transcription factor MML-1. Genome-wide chromatin localization profiling of transcription factor MML-1

MML-1 (Myc and Mondo-Like) encodes a Myc superfamily protein which, together with its partner MXL-2 (Max-like), regulates lifespan via distinct gene sets important for longevity. It is also required for normal migration of ray precursor cells in the male tail and for proper epidermal expression of extracellular matrix component genes. MML-1 binds to MXL-2, required for its protein stability. The MML-1/MXL-2 complex activate transcription mostly via E-box elements. Overall design: Profiling of MML-1 chromatin localization in wild-type third larval (L3) stage Caenorhabditis elegans