Molecular alterations in the motor and somatosensory areas of the juvenile NeuroD2 deficient mouse

We found morphofunctional alterations in the neocortex of NeuroD2 deficient mice that were associated with autism/schizophrenia-like behaviors. Thus we asked what are the NeuroD2 target genes that are modified in NeuroD2 deficient mice. In particular it was interesting to determine which genes could be related with morphofunctional alterations and autism/schizophrenia Overall design: In P28 mice we micro-dissected motor plus somatosensory areas, the regions where we found morphofunctional alterations, and performed RNA purification, library preparation and RNA sequencing