Data shown here correspond to dose-response curves shown in Figures 5 and 6 and Figure S8. Interpretation of combination indices is provided in the Materials and Methods section.
wt, wild type CaSR; EC50 [Ca2+]o, extracellular calcium concentration giving half maximal response determined from normalized data; 95% CI, 95% confidence interval. The p-values for the regression fit
A dose–response curve is essential for determining the safe dosage of a drug and is widely used in bioassay and in phase 1 clinical trials. It is generally accepted that the probability of death or th