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Maladaptive upregulation of aminoprocalcitonin fuels seizure self-sustaining by boosting energy supply in refractory status epilepticus

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To investigate the biological functions of aminoprocalcitonin (NPCT) and its parent peptide procalcitonin (PCT) in neurons, we stimulated rat primary hippocampal neurons at DIV7 with 1 nM NPCT and 1 nM PCT for 24 h, respectively. Alterations in transcriptomes were analyzed with RNA-seq.

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