A direct comparison in terms of the Areas Under the Curve (AUC) and oral doses associated with a 99% reduction of cfu counts in the lungs of infected mice (ED99) compared to untreated control for rifampicin, isoniazid, moxifloxacin and compound 9.

aDose that reduces 2 logs bacterial burden in the lungs of mice (acute phase). Data are calculated from individual log10CFU/lungs fitted to a logistic equation. Data are expressed as ED99 (mg/kg) and the confidence interval of ED99 at 95% (in parenthesis).bAUCinf of 0.98 mg/Kg single oral dose.cAUCinf of 10.4 mg/Kg single oral dose.dAUCinf of 27.5 mg/Kg single oral dose.eAUCinf of 50 mg/Kg single oral dose.