Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437 Descriptor: CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ... Authors: Da, C, Zhang, D, Stashko, M.A, Cheng, A, Hunter, D, Norris-Drouin, J, Graves, L, Machius, M, Miley, M.J, DeRyckere, D, Earp, H.S, Graham, D.K, Frye, S.V, Wang, X, Kireev, D. Deposit date: 2018-09-06 Release date: 2019-09-11 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.893 Å) Cite: Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology. J.Am.Chem.Soc., 141, 2019

原癌基因酪氨酸蛋白激酶MER（proto-oncogene tyrosine-protein kinase MER）催化结构域与抑制剂UNC3437结合的晶体结构。相关配体：氯离子（CHLORIDE ION）、镁离子（MAGNESIUM ION）以及酪氨酸蛋白激酶Mer（Tyrosine-protein kinase Mer）等。作者：Da, C、Zhang, D、Stashko, M.A、Cheng, A、Hunter, D、Norris-Drouin, J、Graves, L、Machius, M、Miley, M.J、DeRyckere, D、Earp, H.S、Graham, D.K、Frye, S.V、Wang, X、Kireev, D。沉积日期：2018-09-06；发布日期：2019-09-11；最后修改日期：2024-03-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.893 Å。引用文献：《具有可控多药理学特性的抗肿瘤药物的数据驱动构建（Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology）》，发表于《美国化学会志》（J.Am.Chem.Soc.），第141卷，2019年。