Investigating the Real-World Experience of Enhancing Occipital Hair Diameter Index in Male Androgenetic Alopecia

Androgenetic Alopecia (AGA) is a condition that causes gradual hair thinning and baldness in certain areas of the scalp. Male Pattern Hair Loss (MPHL) affects the frontotemporal and vertex regions, while Female Pattern Hair Loss (FPHL) presents as diffuse thinning of the central scalp with a preserved hairline. Historically, the occipital region was considered an unaffected area of AGA, leading to little research on the efficacy of alopecia medication in this area. 1 However, recent studies have shown that both MPHL and FPHL can cause changes in the occipital hair and contribute to AGA, highlighting the importance of investigating the effects of drugs like finasteride on the occipital region.This study aimed to fill the gap in real-world scenarios by retrospectively reviewing patients treated with finasteride at our clinic for 6 months or longer. We evaluated the changes in occipital hair thickness and measured various hair parameters under digital trichoscope of MPHL and FPHL patients before and after treatment. Using the Hair Diameter Index to estimate visual hair density range, we were able to quantify the changes observed. The favorable outcome regarding the use of finasteride may provide citable evidence for medication prior to hair transplant surgery.雄激素性脱发（Androgenetic Alopecia, AGA）是一种可导致头皮特定区域毛发逐渐稀疏乃至秃发的病症。男性型脱发（Male Pattern Hair Loss, MPHL）常累及额颞区与头顶区，而女性型脱发（Female Pattern Hair Loss, FPHL）则表现为头皮中央区域弥漫性毛发稀疏，且发际线完整保留。既往研究将枕部区域视为雄激素性脱发的未受累区域，因此针对该区域脱发药物的疗效研究寥寥无几[1]。然而近期研究证实，男性型脱发与女性型脱发均可引发枕部毛发的改变，并参与雄激素性脱发的发生发展，这凸显了探究非那雄胺等药物对枕部区域作用效果的重要性。 本研究旨在填补真实世界研究领域的空白，对本诊所内接受非那雄胺治疗6个月及以上的患者开展回顾性分析。我们评估了男性型脱发与女性型脱发患者在治疗前后的枕部毛发厚度变化，并通过数码毛发镜测量了多项毛发参数。借助毛发直径指数估算视觉毛发密度范围，我们实现了对观察到的毛发变化的量化分析。本研究中关于非那雄胺应用的积极结果，可为毛发移植术前的药物干预提供可引用的循证证据。