Data for: Comparison of parameters affecting GNP-loaded choroidal melanoma dosimetry; Monte Carlo study

The results of our study indicate the significance of using a full Monte Carlo model of human eye globe instead of water phantom for the sake of precise ophthalmic dosimetry in the presence of GNPs. The significance of GNPs’ size effect on macroscopic dose enhancement in choroidal melanoma was also demonstrated, with implications on larger diameter GNPs in combination with a high concentration depositing more energy on a macroscopic level. This study also specifies the efficacy of low energy photon sources in the presence of GNPs in yielding a high dose to the region of interest. Experimental works on a wide range of sizes and concentrations of GNPs is a prerequisite in the precise brachytherapy treatment of choroidal melanoma which will be conducted in future studies.本研究结果表明，在金纳米颗粒（Gold Nanoparticles, GNPs）存在的情况下，为实现精准眼科剂量学（ophthalmic dosimetry），采用完整蒙特卡洛模型（Monte Carlo model）模拟人类眼球体而非水模体（water phantom）具备重要意义。本研究同时证实了金纳米颗粒尺寸效应对脉络膜黑色素瘤（choroidal melanoma）宏观剂量增强（macroscopic dose enhancement）的重要性，提示更大粒径的金纳米颗粒配合高浓度可在宏观层面沉积更多能量。此外，本研究明确了在金纳米颗粒存在时，低能光子源（low energy photon sources）可向感兴趣区域（region of interest）递送高剂量的有效性。针对不同尺寸与浓度金纳米颗粒的系统性实验，是未来开展脉络膜黑色素瘤精准近距离放射治疗（brachytherapy）研究的必要前提。