Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with N-Methyl-2-pyrrolidone (NMP)

Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with N-Methyl-2-pyrrolidone (NMP) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-methylpyrrolidin-2-one, ATPase family AAA domain-containing protein 2, ... Authors: Chaikuad, A, Felletar, I, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2014-07-06 Release date: 2014-07-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain MedChemComm, 5, 2014

人类ATP酶家族AAA结构域包含蛋白2（ATAD2）的溴结构域（bromodomain）与N-甲基-2-吡咯烷酮（NMP）复合物的晶体结构。组分：(4S)-2-甲基-2,4-戊二醇、1-甲基吡咯烷-2-酮、ATP酶家族AAA结构域包含蛋白2等。作者：Chaikuad A、Felletar I、von Delft F、Arrowsmith C.H、Edwards A.M、Bountra C、Knapp S，结构基因组学联盟（SGC）。提交日期：2014-07-06。发布日期：2014-07-23。最后修改日期：2023-09-20。实验方法：X射线衍射（分辨率2埃）。引用文献：《靶向低成药性ATAD2溴结构域的片段发现的基于结构研究策略》，发表于《MedChemComm》，第5卷，2014年。