Target Pathogen

The Target-Pathogen database is a bioinformatic approach to prioritize drug targets in pathogens. Available genomic data for pathogens has created new opportunities for drug discovery and development, including new species, resistant and multiresistant ones. However, this data must be cohesively integrated to be fully exploited and be easy to interrogate. Target-Pathogen has been designed and developed as an online resource to allow genome wide based data consolidation from diverse sources focusing on structural druggability, essentiality and metabolic role of proteins. By allowing the integration and weighting of this information, this bioinformatic tool aims to facilitate the identification and prioritization of candidate drug targets for pathogens. With the structurome and drugome information Target-Pathogen is a unique resource to analyze whole genomes of relevants pathogens.Target-Pathogen数据库（Target-Pathogen Database）是一款用于对病原体药物靶点进行优先级排序的生物信息学工具。当前可获取的病原体基因组数据为药物研发带来了全新机遇，涵盖新型病原体以及耐药、多重耐药病原体。然而，此类数据需经有机整合，方能得到充分利用且便于查询。该数据库作为一款在线资源开发设计，旨在整合多源全基因组相关数据，重点关注蛋白质的结构可药性、必需性与代谢功能。通过实现此类信息的整合与权重赋值，这款生物信息学工具旨在助力病原体候选药物靶点的识别与优先级排序工作。依托结构组（structurome）与药物组（drugome）数据，Target-Pathogen数据库是一款可用于分析相关病原体全基因组的独特资源。

搜集汇总

背景与挑战

背景概述

Target-Pathogen数据库是一个生物信息学在线资源，通过整合病原体的基因组数据，聚焦蛋白质的结构可药性、必需性和代谢作用，以促进候选药物靶点的识别与优先级排序。它结合结构组和药物组信息，为分析相关病原体的全基因组提供了独特工具。