Structure of PKA complexed with 4-(4-Chlorobenzyl)-1-(7H-pyrrolo(2,3- d)pyrimidin-4-yl)piperidin-4-ylamine

Structure of PKA complexed with 4-(4-Chlorobenzyl)-1-(7H-pyrrolo(2,3- d)pyrimidin-4-yl)piperidin-4-ylamine Descriptor: 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... Authors: Caldwell, J.J, Davies, T.G, Donald, A, McHardy, T, Rowlands, M.G, Aherne, G.W, Hunter, L.K, Taylor, K, Ruddle, R, Raynaud, F.I, Verdonk, M, Workman, P, Garrett, M.D, Collins, I. Deposit date: 2008-02-08 Release date: 2008-04-08 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Identification of 4-(4-Aminopiperidin-1-Yl)-7H-Pyrrolo[2,3-D]Pyrimidines as Selective Inhibitors of Protein Kinase B Through Fragment Elaboration. J.Med.Chem., 51, 2008

结合4-(4-氯苄基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-胺的蛋白激酶A（PKA）复合物结构
描述信息：4-(4-氯苄基)-1-(7H-吡咯并[2,3-d]嘧啶-4-基)哌啶-4-鎓离子、环腺苷酸依赖型蛋白激酶抑制剂α、环腺苷酸依赖型蛋白激酶……
作者：Caldwell, J.J.、Davies, T.G.、Donald, A.、McHardy, T.、Rowlands, M.G.、Aherne, G.W.、Hunter, L.K.、Taylor, K.、Ruddle, R.、Raynaud, F.I.、Verdonk, M.、Workman, P.、Garrett, M.D.、Collins, I.
提交日期：2008-02-08
发布日期：2008-04-08
最后更新：2024-11-06
实验方法：X射线衍射（分辨率1.98 Å）
引用文献：《通过片段拓展法鉴定4-(4-氨基哌啶-1-基)-7H-吡咯并[2,3-d]嘧啶类化合物作为蛋白激酶B的选择性抑制剂》，《药物化学杂志》（J.Med.Chem.），第51卷，2008年