CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c1(ccccc1)c2cn(C)c(n2)CCC3=Nc4c(C(N3)=O)cnn4C, micromolar IC50=0.04979

Protein Data Bank Japan2025-08-06 更新2026-03-21 收录

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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c1(ccccc1)c2cn(C)c(n2)CCC3=Nc4c(C(N3)=O)cnn4C, micromolar IC50=0.04979 Descriptor: 1-methyl-6-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethen-1-yl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Groebke-Zbinden, K, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2025-08-06 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人源磷酸二酯酶10（human phosphodiesterase 10）与c1(ccccc1)c2cn(C)c(n2)CCC3=Nc4c(C(N3)=O)cnn4C复合物的晶体结构，半数抑制浓度（IC50）为0.04979微摩尔。描述项：1-甲基-6-[(E)-2-(1-甲基-4-苯基-1H-咪唑-2-基)乙烯-1-基]-1,5-二氢-4H-吡唑并[3,4-d]嘧啶-4-酮、镁离子、锌离子等。作者：Joseph C、Benz J、Flohr A、Groebke-Zbinden K、Rudolph M.G. 入库日期：2022-02-01；发布日期：2022-10-12；最后修改日期：2025-08-06。检测方法：X射线衍射（2.77埃）。引用文献：《人源磷酸二酯酶10复合物的晶体结构》，待发表

创建时间：

2022-02-01