Are there Differences regarding the Blood Pressure Response between Vaccinated/Unvaccinated Patients Hospitalized for COVID-19 at more than 6 Month after the last Doze of Vaccine?

Background: A major problem often encoutered in hospitalized patients with the corona virus 2 (COVID-19) disease is the management of blood pressure (BP) values. This study aims to analyze the evolution of BP values in hospitalized patients and to assess the impact of vaccination on their clinical outcome. (2) Methods: This retrospective study contains 85 patients divided into 2 groups: group A-39 vaccinated patients and group B – 46 unvaccinated patients admitted in the Infectious Diseases Clinic 1 of the Victor Babes Hospital Timisoara during the 6th wave of COVID-19 pan-demic. None of the subjects, even those diagnosed with systemic hypertension (SHT), had BP values over 150/90 mmHg at admission. The severity of COVID-19 was determined based on the thorax computed-tomography findings and spontaneous peripheral oxygen saturation. (3) Results: During hospitalization, the BP values were lower in group A compared to group B and vaccinated patients had fewer comorbidities. The multilinear regression model determined that in both groups, inflammatory markers had statistically significant influence over the systolic BP values at discharge. (4) Conclusions: The study suggests that vaccination may have a positive impact on BP values and on the clinical outcome of patients with COVID-19.
The study was conducted by the researchers from the University of Medicine and Pharmacy Victor Babes.

背景：新型冠状病毒2型（COVID-19）住院患者的血压（BP）管理是临床常见难题。本研究旨在分析住院患者的血压动态变化，并评估疫苗接种对其临床结局的影响。
(2) 方法：本回顾性研究纳入85例患者，分为两组：A组39例接种疫苗患者，B组46例未接种疫苗患者，均为蒂米什瓦拉维克托·巴贝斯医院第一传染病科在COVID-19大流行第6波期间收治的病例。所有受试者，即便确诊为系统性高血压（SHT）者，入院时血压均未超过150/90 mmHg。新冠病情严重程度通过胸部计算机断层扫描（computed tomography，CT）结果及自发性外周血氧饱和度进行评估。
(3) 结果：住院期间，A组患者的血压水平显著低于B组，且接种疫苗的患者合并症更少。多元线性回归模型显示，两组患者的炎症标志物均对出院时的收缩压存在统计学意义上的显著影响。
(4) 结论：本研究表明，疫苗接种或可对COVID-19患者的血压水平及临床结局产生积极影响。本研究由维克托·巴贝斯医科大学的研究人员开展。