Cutaneous Squamous Cell Carcinoma in Patients with Solid Organ Malignancy Supplemental Table 1

The objective of this study is to evaluate the incidence, tumor characteristics, and outcomes of cSCC in patients with SOM compared to patients with no history of SOM. We conducted a multivariate analysis to examine the association between solid organ malignancy and poor outcomes. Based on univariate analysis, models were adjusted for age, gender, and BWH stage. However, the findings did not reveal significant associations between history of solid organ malignancy and development of poor outcomes (Supplemental Table 1). Overall, the findings of this study indicate an elevated incidence of high-stage cutaneous squamous cell carcinoma among individuals with a prior history of solid organ malignancy. However, no definitive associations were established been SOM and adverse outcomes. Additional research is warranted to thoroughly examine the interplay between solid organ malignancy, cSCC tumorigenesis, and disease outcomes.本研究旨在评估伴实体器官恶性肿瘤（solid organ malignancy, SOM）患者与无实体器官恶性肿瘤病史患者的皮肤鳞状细胞癌（cutaneous squamous cell carcinoma, cSCC）发病率、肿瘤特征及预后情况。我们开展多变量分析以探究实体器官恶性肿瘤与不良预后之间的关联。基于单因素分析结果，对模型校正了年龄、性别以及BWH分期这几项变量。然而，研究结果并未显示实体器官恶性肿瘤病史与不良预后发生之间存在显著关联（补充表1）。总体而言，本研究结果表明，既往有实体器官恶性肿瘤病史的个体中，高分期皮肤鳞状细胞癌的发病率有所升高。但并未明确实体器官恶性肿瘤与不良预后之间存在确切关联。仍需开展进一步研究，以全面探究实体器官恶性肿瘤、皮肤鳞状细胞癌发生发展与疾病预后之间的相互作用。