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Highly Enantioselective Friedel−Crafts Alkylations of Pyrroles and Indoles with α‘-Hydroxy Enones under Cu(II)-Simple Bis(oxazoline) Catalysis

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NIAID Data Ecosystem2026-03-06 收录
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Remarkably high and regular enantioselectivities are obtained in Friedel−Crafts alkylation reactions involving α‘-hydroxy enone templates and Cu(II)−bis(oxazoline) complexes as catalysts. The simple elaboration of adducts provides a route to enantioenriched aldehydes, carboxylic acids, and ketones containing the pyrrole and indole frameworks.

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2016-05-06
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