Asymmetric Organocatalytic Reductive Coupling Reactions between Benzylidene Pyruvates and Aldehydes
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https://figshare.com/articles/dataset/Asymmetric_Organocatalytic_Reductive_Coupling_Reactions_between_Benzylidene_Pyruvates_and_Aldehydes/2092876
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资源简介：
An
organocatalytic three-component reductive coupling reaction
between dimethyl phosphite, benzylidene pyruvates, and aldehydes is
reported. A chiral triaryliminophosphorane catalyst promotes
Pudovik addition, which is followed by phospha-Brook rearrangement
to transiently generate enolates that are trapped stereoselectively
by aldehydes. This reductive coupling provides vicinal polyfunctionalized
stereocenters from readily available prochiral starting materials
with excellent diastereoselectivity, enantioselectivity, and yield.
创建时间：
2016-02-12
