Single cell transcriptome of human intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy within the liver, with a high degree of tumor heterogeneity and a very poor prognosis. In this study, single-cell transcriptome sequencing analysis was performed on 3 samples (1 plasma, 1 tumor and 1 paracancerous tissue) from an ICC patient with the aim of studying cell type variations in different tissue types. To investigate the distribution of bacterial transcription products in various cell types, we analyzed ICC scRNA-seq data. In this study, we obtained single cell RNA-seq data from a total of 3 tissue samples (1 tumor tissue, 1 paracancer tissue and 1 plasma tissue) from 1 ICC patient, yielding a total of 11357 cells for subsequent clustering analysis.