Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
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Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, A12 antibody heavy chain, A12 antibody light chain, ... Authors: Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. Deposit date: 2022-05-23 Release date: 2023-06-07 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (3.38 Å) Cite: Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
新型抗间皮素（Mesothelin）抗体实现完整间皮素胞外域（ectodomain）的晶体结构解析及强效T细胞衔接双特异性治疗药物的工程化开发
描述项：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、A12抗体重链、A12抗体轻链……
作者：Bandaranayake, A.D.、Rupert, P.B.、Lin, I.、Pilat, K.、Ruff, R.O.、Friend, D.J.、Chan, M.K.、Clarke, M.、Carter, J.、Meshinchi, S.、Mehlin, C.、Olson, J.M.、Strong, R.K.、Correnti, C.E.
提交日期：2022-05-23
发布日期：2023-06-07
最后修改日期：2024-11-13
实验方法：X射线衍射（X-RAY DIFFRACTION，3.38 Å）
引用文献：《新型间皮素抗体实现完整间皮素胞外域晶体结构解析及强效T细胞衔接双特异性治疗药物的工程化开发》，《前沿药物发现》（Front. Drug Discov.），第3卷，2023年
创建时间：
2022-05-23
