Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation.

Transcriptomes of the Group I CBS1538 and the Group II W 34/70 S. pastorianus strains were analysed to specifically examined the contribution of the two sub-genomes to the gene expression patterns under fermentations conditions. Using de novo genome sequencing of these strains, gene expression patterns were related to gene copy numbers to investigate if the relative expression of S. cerevisiae and S. eubayanus orthologues is directly correlated to gene copy number in the Group II strain.