The effects of Zoledronate on human peripheral blood mononuclear cells. The effects of Zoledronate on human peripheral blood mononuclear cells

Zoledronate is well known to act on osteoclasts to inhibit bone resorption.Zoledronate is administrated intravenously in clinical use, however, actions of zoledronate on cells in blood circulation are not fully understood. To understand its actions of human peripheral blood mononuclear cells (h-PBMC), we performed gene expression profiling in zoledronate-treated h-PBMC. Overall design: h-PBMC were incuvated for 8 hours with 5 mM of Zoledronate (Zol. (+)) or without (Zol. (-)).