Total Synthesis of 7′-Desmethylkealiiquinone
收藏数据链接：
官方服务：
资源简介：
The total synthesis of an analogue of the marine alkaloid kealiiquinone has been completed through application of an intramolecular Diels–Alder reaction of an imidazole-containing enyne. Oxidative aromatization of the lactone adduct and N-methylation facilitates C2-oxidation via the imidazolium salt. Conversion of the lactone to the phthalaldehyde derivative and then to the dihydroxybenzoquinone was achieved via a reaction with glyoxal in the presence of KCN. Esterification of the vinylogous diacid and deprotection provided 7′-desmethylkealiiquinone.
创建时间：
2016-02-21
