26S proteasome degrades HIFalpha

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

本事件系基于另一物种中已证实的事件，通过计算推断而来。推断过程基于PANTHER的保守性映射。简言之，对于所有涉及的物理实体（包括输入、输出和催化剂）均存在同源或直系同源映射的反应（对于复合体而言，至少75%的组分需进行映射），将其推断至其他物种。此外，对于这些事件，还推断出高级别事件，以便于更便捷的导航。<p>有关Reactome中事件推断的更多细节及注意事项，请参阅：<a href='/electronic_inference_compara.html' target = 'NEW'>事件推断详情与注意事项</a>。关于PANTHER的详细信息，请参见：<a href='http://www.pantherdb.org/about.jsp' target='NEW'>PANTHER简介</a>。

搜集汇总

背景与挑战

背景概述

该数据集描述了26S蛋白酶体降解HIF-alpha蛋白的分子通路事件，主要涉及VHL-E3泛素连接酶复合物介导的泛素化降解机制。该事件通过计算推断从人类同源映射到热带爪蟾物种，实验证据表明HIF-alpha在再氧化的缺氧细胞中通过氧调节的脯氨酰羟化作用被靶向降解。