Additional file 1 of Mechanistic intersections between migraine and major depressive disorder

Supplementary Material 1: Table S1. Studies in humans and rodents providing evidence of role of PACAP in migraine and MDD. This table summarizes key papers from clinical and preclinical data indicating a role for PACAP in MDD and migraine. Papers focused on human data is in darker colors with MDD-related papers in blue and migraine-related papers in orange. Where a large number of papers were found to demonstrate similar results, we have included those that provide sufficient differences in the conditions that provide insight into the different conditions by which PACAP influences disease and related behaviors, prioritizing papers with both sexes wherever possible and those with higher n and multiple metrics